Growing Inflammation

The ‘Growing End’ of Inflammation was Discovered

Redness, swelling, pain — these are signs of inflammation. It serves to protect the body from pathogens or foreign substances. Researchers from the Universities of Bonn and Cologne were able to show that inflammatory reactions of an important sensor protein proceed in a specific spatial direction. This finding has the potential to conceivably stop inflammation…

*. Redness, swelling, and pain are all signs of inflammation. It protects the body against foreign substances and pathogens. Researchers at the Universities of Bonn, Cologne and Cologne showed that inflammation reactions of an important sensor proteins occur in a particular spatial direction. This discovery could potentially stop inflammation at its “growing end” and bring an end to chronic inflammatory diseases. The study was published in the journal “Science Advances . “

If bacteria or viruses infect living cells, or foreign substances are found in them, the danger detector with the abbreviation NLRP3 activates. Professor Matthias Geyer, from the Institute for Structural Biology, University Hospital Bonn, refers to previous studies. These studies show that this reaction fuels itself more than ever. The inflammatory reaction triggered NLRP3 encourages further amyloid-ss deposits and contributes significantly towards the disease process.

As soon as the NLRP3 proteins are activated, they attach to one another and form a nucleus that allows for more proteins to gather. Geyer reports that the reaction starts as soon as there are about a dozen NLRP3 molecules present. The theory is that an infinitum of NLRP3 molecules could join together to extend the thread-like structure, scientifically known as a “filament”, further and further. Professor Geyer’s team now has Inga Hochheiser to explain the way that this filament expands and grows. These insights were obtained using cryo-electron microscopescopy. This method makes it possible to observe protein molecules with up to 80,000-fold magnification and thus make them directly visible,” says Hochheiser.

“Still image” of the thread-like structure under the microscope

In tiny steps, the scientist poured NLRP3 from cells onto a carrier and flash-froze the mixture. The researchers were able to see a “still image” of the mixture under the cryoelectron microscope. This allowed researchers to visualize the thread-like structure of NLRP3 molecules arranged side-by-side. “These individual images made it po

Read More

Leave a Reply

Your email address will not be published.