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Computer modeling of blood enzymes may help to develop new medications for heart disease

Lp-PLA2 in its “closed” conformation (left) and “open” conformation (right) once bound to the phospholipid monolayer. Credit: UC San Diego Health Sciences Membrane-associated proteins play a vital role in a variety of cellular processes, yet little is known about the membrane-association mechanism. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is one such protein with an important role in…

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